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Bio-Techne corporation
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Image Search Results
Journal: Mediators of Inflammation
Article Title: Baicalein Restores the Balance of Th17/Treg Cells via Aryl Hydrocarbon Receptor to Attenuate Colitis
doi: 10.1155/2020/5918587
Figure Lengend Snippet: Effects of baicalein on cytokines in the serum of DSS-induced colitis mice: (a) IL-6; (b) TNF- α ; (c) IL-17; (d) TGF- β ; (e) IL-10; (f) IL-22. Results were means ± S.E.M.# P < 0.05 and ## P < 0.01 vs. control group; ∗ P < 0.05, ∗∗ P < 0.01, and ∗∗∗ P < 0.001 vs. model group. CH: CH223191; CH+B: CH223191+baicalein.
Article Snippet: IL-10 and IL-17A enzyme-linked immune sorbent assay (ELISA) kits were purchased from MultiSciences Biotech (Hangzhou, China); IL-6, TNF- α ,
Techniques:
Journal: Mediators of Inflammation
Article Title: Baicalein Restores the Balance of Th17/Treg Cells via Aryl Hydrocarbon Receptor to Attenuate Colitis
doi: 10.1155/2020/5918587
Figure Lengend Snippet: Schematic representation of the mechanism in baicalein-induced Treg cell differentiation through AhR against UC. The balance of Th17/Treg cells in the intestinal of DSS-induced colitis mice was disrupted, leading to hyperactive proinflammatory response, insufficient anti-inflammatory response, aggravating intestinal inflammation, and tissue damage. Baicalein promoted Treg cell differentiation by activating AhR. Meanwhile, baicalein reduced levels of IL-6 and increased levels of TGF- β in colitis mice, which impeded the initiation of Th17 cell differentiation. Moreover, baicalein regulated the balance of proinflammatory cytokines such as IL-17, IL-6, and TNF- α and anti-inflammatory cytokines such as IL-10 and TGF- β , which controlled intestinal immune homeostasis and reduced inflammatory damage.
Article Snippet: IL-10 and IL-17A enzyme-linked immune sorbent assay (ELISA) kits were purchased from MultiSciences Biotech (Hangzhou, China); IL-6, TNF- α ,
Techniques: Cell Differentiation